SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication




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March 16, 2017
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SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication Leading to stable gene Silencing



Highlights
•SMARCAD1 homolog Fft3 suppresses histone turnover to promote epigenetic inheritance
•Fft3 facilitates epigenetic transmission of heterochromatin in dividing cells
•Stabilization of nucleosomes at genes prevents R-loop replication barriers
•Clr4/Suv39h suppresses R-loop accumulation and silencing defects in fft3Δ cells

Summary

Heterochromatin can be epigenetically inherited in cis, leading to stable gene silencing. However, the mechanisms underlying heterochromatin inheritance remain unclear. Here, we identify Fft3, a fission yeast homolog of the mammalian SMARCAD1 SNF2 chromatin remodeler, as a factor uniquely required for heterochromatin inheritance, rather than for de novo assembly. Importantly, we find that Fft3 suppresses turnover of histones at heterochromatic loci to facilitate epigenetic transmission of heterochromatin in cycling cells. Moreover, Fft3 also precludes nucleosome turnover at several euchromatic loci to prevent R-loop formation, ensuring proper replication progression. Our analyses show that overexpression of Clr4/Suv39h, which is also required for efficient replication through these loci, suppresses phenotypes associated with the loss of Fft3. This work uncovers a conserved factor critical for epigenetic inheritance of heterochromatin and describes a mechanism in which suppression of nucleosome turnover prevents formation of structural barriers that impede replication at fragile regions in the genome.
Journal Reference:
Nitika Taneja 
Martin Zofall 
Gobi Thillainadesan 

SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication. DOI: http://dx.doi.org/10.1016/j.molcel.2017.02.006


This is as much as we can get, the detailed information is not yet publicly published but it is quite insuring that the Epigenetic inheritance is possible and SNF2 family Proteins are showing remarkable participation in suppression of nucleosome turnover to promote epigenetic inheritance and promote replication in such a way that not only we can say that they participate in gene expression but also control its dormant and its recessive forms.
Further Information will be added as the research material get publicly published.    

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