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SOURCE: Date : For Full Report Click He March 16, 2017 Source : No Information Available  SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication Leading to stable gene Silencing Highlights •SMARCAD1 homolog Fft3 suppresses histone turnover to promote epigenetic inheritance •Fft3 facilitates epigenetic transmission of heterochromatin in dividing cells •Stabilization of nucleosomes at genes prevents R-loop replication barriers •Clr4/Suv39h suppresses R-loop accumulation and silencing defects in fft3Δ cells Summary Heterochromatin can be epigenetically inherited in  cis , leading to stable gene silencing. However, the mechanisms underlying heterochromatin inheritance remain unclear. Here, we identify Fft3, a fission yeast homolog of the mammalian SMARCAD1 SNF2 chromatin remodeler, as a factor uniquely required for heterochromatin inheritance, rather than for de novo assembly. Importan...

SOURCE: Date : For Full Report Click Here March 28, 2017 Source : University of California - San Diego Summary : Bioengineers have discovered a protein that regulates the switch of embryonic stem cells from the least developed 'naïve' state to the more developed 'primed' state. This discovery sheds light on stem cell development at a molecular level. Bioengineers at the University of California San Diego have discovered a protein that regulates the switch of embryonic stem cells from the least developed "naïve" state to the more developed "primed" state. This discovery sheds light on stem cell development at a molecular level. The findings were published online in  Cell Reports  on March 28. "This discovery provides a fine-tuning knob for the stem cell engineering toolkit," said Sheng Zhong, a bioengineering professor at the UC San Diego Jacobs School of Engineering and the study's senior author. "A number of pre...