BanarasiScience

Source:- Source link Human life clock also know as circadian clock is not only responsible for timing our sleep, but it can effect out eating, social and economical behavior. This can be seen now a days with most of the young and working people. A scientific paper posted on www.cell.com tell us about the relation between our circadian system and our eating habits and at which time do we prefer to take our food in a day. It was seen that people having their meal after of before their eating time had much less sleep or had trouble sleeping. Highlights • A 5-hr delay in meal times changes the phase relationship of human circadian rhythms • Plasma glucose, but not insulin or triglyceride, rhythms are delayed by late meals • Adipose  PER2  rhythms are delayed by late meals • Rhythm changes occur without altered subjective or actigraphic sleep markers Summary Circadian rhythms, metabolism, and nutrition are intimately linked [ 1 ,  2 ], althou...

Highlights • A human subject with DSPD with a variation in  CRY1  has altered circadian rhythms • Proband kindred and unrelated carrier families display aberrant sleep patterns • The allele alters circadian molecular rhythms • The genetic variation enhances CRY1 function as a transcriptional inhibitor Summary Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ∼24 hr rhythms in many behavioral and physiological processes. This system is altered in delayed sleep phase disorder (DSPD), a common form of insomnia in which sleep episodes are shifted to later times misaligned with the societal norm. Here, we report a hereditary form of DSPD associated with a dominant coding variation in the core circadian clock gene  CRY1 , which creates a transcriptional inhibitor with enhanced affinity for circadian activator proteins Clock and Bmal1. This gain-of-function  CRY1  variant causes reduced ...